Cure Rates and Efficacy Of Newer Hep C Drugs
Sustained virology response (SVR) was used to determine the effectiveness of hep c medications across all the clinical trials. SVR means that the virus is undetectable in the blood 12 weeks after treatment. This signifies that hepatitis c has been cured.
Cure rates differ based on patient condition (cirrhosis, no cirrhosis, treatment experience, co-infection) and genotype.
All the drugs have the potential to achieve 100% cure rate in certain hep c patient populations.
It should be noted that the majority of cure rates are above 90%, most cure rates below 85% are seen in special patient populations. For example, the lowest cure rate for Daklinza is 33%, but that is from two out of six patients with genotype 1a and cirrhosis.
Viekira Pak: 89-100%
Duration of Hepatitis C Treatment Regimens
The shortest regimen available is 8 weeks treatment with Mavyret, which is approved for all 6 genotypes.
All medications have at least one 12-week regimen.
have pretreatment HCV RNA <6 million IU/mL.
Epclusa: Only has a 12-week regimen
Daklinza,: Genotype 1 and 3 with or without cirrhosis.
Technivie: Genotype 4
16 weeks regimen:
24 weeks regimen:
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