4. Nicotinic acid (Niacin)
Nicotinic acid is used for the treatment of hypercholesterolemia (high cholesterol). Niacin can cause an increase in blood glucose and possibly worsen glucose control in diabetic patients. Niacin can increase glucose production in the liver which causes the increase in blood glucose. Statins are an alternative to niacin if glucose control is a concern.
5. Statins (rosuvastatin, atorvastatin, simvastatin, lovastatin)
Statins have also been associated with increased blood glucose and increased risk of diabetes. Pravastatin is the only statin that is not associated with increasing blood glucose. Although there is conflicting evidence, the overall risk of developing diabetes from statins is low. Patients should be kept on statins because they prevent cardiovascular events and death. These benefits outweigh the small risk of developing diabetes.
6. Thiazide diuretics (Hydrochlorothiazide, chlorthalidone, chlorothiazide, indapamide)
Thiazide diuretics are commonly used for treating hypertension (high blood pressure). They are associated with increasing blood glucose and risk of developing diabetes. The increase in blood glucose may be caused by decreased insulin secretion and increased insulin resistance. Thiazides are usually given at low doses and have a small effect on blood glucose. Thiazides are used for treating hypertension in diabetics because their benefits on blood pressure control outweigh their effect on glucose levels. Alternative hypertensives may be used if thiazides significantly affect blood glucose control.