Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
NTRIs disrupt the HIV RNA by changing a nucleoside, one of the main building blocks of genetic material. This prevents the enzyme ‘reverse transcriptase’ from changing HIV RNA to HIV DNA. Common side effects of NRTIs include fatigue, headache, insomnia, malaise, migraine, nausea, nightmares, and vomiting.
Brand and Generic Names of Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
NNRTIs block reverse transcriptase, which is the enzyme that converts HIV RNA to HIV DNA. Common side effects from NNRTIs include anxiety, depression, diarrhea, dizziness, elevated hepatic enzymes, erythema, hypercholesterolemia, hypertriglyceridemia, insomnia, rash, nausea, neutropenia, pruritus, and urticaria. Examples of NNRTIs are listed below.
Brand and Generic Names of Non-nucleoside Reverse Transcriptase Inhibitors (NNRTIs)
HIV Protease Inhibitors (PIs)
Protease inhibitors bind the enzyme ‘protease’ which is responsible for cleaving polyproteins, made from viral DNA, into viral proteins to form a new HIV retrovirus. This results in the formation of immature noninfectious viral particles. Common side effects of protease inhibitors include a cough, fever, hyperamylasemia, hyperbilirubinemia, hypercholesterolemia, jaundice, lipodystrophy or degeneration of fat tissue, nausea, rash, and vomiting. Examples of HIV Protease Inhibitors are listed below.
Brand and Generic Names of Protease Inhibitors